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多次视网膜激光光凝对角膜内皮的影响:

多次视网膜激光光凝对角膜内皮的影响
The changes of corneal endothelium after the repeatedly treatment of Retinal laser photocoagulation
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作　　者：刘露刘世纯徐霁李春华吕莎宋胜仿
LIU lu,LIU Shi-chun,XU Ji,LI Chun-hua,LV Sha,SONG Sheng-fang（Department of Ophthalmology, Yong Chuan Hospital, Chong Qing medical university Chongqing 402160,China）
机构地区：重庆医科大学附属永川医院眼科,重庆402160
出　　处：《激光杂志》 CSCD 2015年第36卷第2期 131-134页,共4页
Laser Journal
基　　金：青年课题,编号：YJQN2011034
摘　　要：目的探讨反复多次光凝对角膜内皮细胞（CEC）的影响。方法前瞻性非随机临床研究。选择需行全视网膜激光光凝术的患者55例55眼（均选右眼）,非接触角膜内皮镜检测角膜中央、12点位及6点位的内皮不同参数。采用重复测量的方差分析及LSD检验比较每个参数的变化。结果完成4次激光术后,六角形内皮细胞比例（HEX）在12点位及6点位均有明显改变[12点术前（65.09±18.60）%,术后（63.39±18.39）%,F=1.679;6点术前（64.86±18.48）%,术后（62.95±17.66）%,F=1.978]差异均有统计学意义（P均〈0.05）;变异系数（CV）在角膜中央、12点位及6点位均有明显改变[角膜中央术前（26.24±3.99）%,术后（27.00±4.48）%,F=4.122;12点术前（26.19±4.09）%,术后（27.14±4.47）%,F=4.183;6点术前（26.17±4.34）%,术后（27.38±4.18）%,F=4.079]差异均有统计学意义（P均〈0.05）;平均细胞面积（AVE）在角膜中央、12点位及6点位均有明显改变[角膜中央术前（387.81±49.92）μm2,术后（404.48±50.59）μm2,F=5.136;12点术前（385.71±46.91）μm2,术后（408.38±53.70）μm2;F=5.566;6点术前（388.85±46.02）μm2,术后（406.04±50.71）μm2;F=6.894]差异均有统计学意义（P均〈0.05）;角膜内皮密度（CD）在4次激光术后各位点均减少,但无统计学意义（P均〉0.05）。结论：反复多次视网膜激光光凝术后角膜内皮在短期内有改变,尤其平均细胞面积和变异系数较明显,其改变和激光能量密切相关。
Objective To analyze the changes of corneal endothelium after repeatedly Retinal laser photocoagulation. Methods This was a Prospective nonrandomized clinical study,fifty-five patients 55 eyes（ pick right one） who underwent panrentinal photocoagulation were recruited. The cornea was divided into 3 sections s including central,12 point,6 point. The Corneal endothelial meter was used to collect CECs’ patameter data. The data analysis were done separately by the variance analysis and Least-significant difference. Results Comparing the data before and 28 days after in 3 sections,there were significant difference（ both P 〈0. 05） in the Hexagonal cell percentage（ HEX）（ 12 point changed from 65. 09 ± 18. 60% to 63. 39 ± 18. 39%,F = 1. 679; 6 point changed from 64. 86 ± 18. 48% to 62. 95±17. 66%,F = 1. 978）. And there were significant difference（ all P〈0. 05） in the Coefficient of Variation（ CV）（ cornea from 26. 24 ±3. 99% to 27. 00 ±4. 48%,F = 4. 122; 12 point from 26. 19 ±4. 09% to 27. 14 ±4. 47%,F = 4. 183; 6point from 26. 17 ±4. 34% to 27. 38 ±4. 18%,F = 4. 079. Moreover,there were significant difference（ all P〈0. 05） in the average cell area（ AVE）（ cornea from 387. 81 ± 49. 92μm2to 404. 48 ± 50. 59μm2,F = 5. 136; 12 point from385. 71 ±46. 91μm2to 408. 38 ±53. 70μm2,F =5. 566; 6 point from 388. 85±46. 02μm2to 406. 04 ±50. 71μm2,F =6. 894）. However,the cell density（ CD） was not statistically significant among 3 sections（ all P 〉0. 05）. Conclusion ECEs were changed in a short time after the repeatedly treatment of Retinal laser photocoagulation,especial the Hexagonal cell percentage and the average cell area,it’s highly related to laser energy.
关键词：激光全视网膜光凝糖尿病视网膜病变角膜内皮
laser ;panrentinal photocoagulation ;diabetic retinopathy ;corneal endothelium ;

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